Preclinical Models of Huntington’s Disease
In recognition of Huntington’s Disease (HD) Awareness Month, PsychoGenics is proud to support your HD research needs. With decades of...
Twenty Years of Huntington’s Disease Research at PsychoGenics
C. Torturo and S. Ramboz Over the course of the past 20 years, CHDI and PsychoGenics have worked closely together...
Evidence of Apathy in a Mouse Model of Huntington’s Disease
Huntington’s Disease (HD) is an autosomal dominant neurodegenerative disease caused by a high number of trinucleotide CAG repeats in the...
Neurofilament-light chain protein (NF-L), a biomarker of axon degeneration and neuron death
NF-L is a validated biomarker for assessing disease progression, intensity, and treatment response across a wide range of neurodegenerative disorders...
Characterization of The R6/1 Mouse Model of Huntington’s Disease
The B6.Cg-Tg(HD exon1)61Gpb/J mouse line, or R6/1, is a Huntington’s disease model that carries the human huntingtin gene’s 5’ end...
Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington’s Disease
DOI: 10.3233/JHD-190389 Afshin Ghavami 1, Michael Olsen 1, Mei Kwan 1, Jose Beltran 1, John Shea 1, Sylvie Ramboz 1, Wenzhen Duan 2, Daniel Lavery 3, David Howland 3, Larry C Park 3 Abstract Background: Huntington’s disease (HD) is a progressive...
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease
Zeitler B, Froelich S, Marlen K, Shivak D.A, Yu Q, Li D, Pearl J.R, Miller J.C, Zhang L, Paschon D.E,...
Large-scale phenome analysis defines a behavioral signature for Huntington’s disease genotype in mice.
Alexandrov V, Brunner D, Menalled LB, Kudwa A, Watson-Johnson J, Mazzella M, Russel I, Ruiz MC, Torello J, Sabath E,...
Animal Models of Huntington’s Disease for Translation to the Clinic: Best Practices. Movement Disorders
Menalled L & Brunner D. 29(11): 1375-90 2014
Regional vulnerability in Huntington’s disease: fMRI-guided molecular analysis in patients and a mouse model of disease
Moreno H, Lewandowski N, Bordelon Y, Brickman A, Angulo S, Khan U, Muraskin J, Griffith E, Wasserman P, Menalled L,...