At PsychoGenics, we specialize in measuring compound-target engagement through in vivo and ex vivo receptor occupancy (RO) services. By utilizing selective radioligands and receptor autoradiography, we provide clear and actionable data. Moreover, our receptor autoradiography capabilities help determine tissue distributions of the target of interest and acquire Ki values through displacement assays on brain slices.
Advanced Receptor Occupancy Technology
Harnessing the power of the BeaQuant system (ai4r, France), we’ve transformed traditional assessment practices. This revolutionary technology offers unparalleled high sensitivity (0.0005 cpm/mm2), enabling us to drastically cut down the time needed for specific binding assessment in the brain. With this system, results are achieved in mere hours, as opposed to the weeks required by traditional tritiated ligands. Such an efficient receptor occupancy research approach accelerates the study of compound-target interactions. It not only boosts speed and efficiency but also provides invaluable insights, allowing for more informed, earlier decisions. Furthermore, the speed and precision of the BeaQuant system makes receptor occupancy viable as a screening tool.
Collaborative Research Excellence for Your Next Breakthrough
Leverage PsychoGenics’ expertise in preclinical receptor occupancy services to advance your research and drive breakthroughs in drug development in any therapeutic area. When combined with our suite of preclinical capabilities, our receptor occupancy analysis knowledge aids in drug dosing optimization, better target engagement understanding, and data-driven decision making for improved efficacy and safety. Count on PsychoGenics for consistent, reliable receptor occupancy insights.