Discover Your Next Breakthrough With Comprehensive Preclinical CNS Services

At PsychoGenics, our pioneering strategies and advanced preclinical testing services deliver the high-quality data you need to make critical go/no-go decisions.  Our offerings range from in vivo efficacy testing to pharmacokinetic (PK) and biomarker analyses, all fortified by our extensive knowledge from years of preclinical drug discovery research. 

Preclinical CNS Service Types

Behavioral and In Vivo Testing

Our capabilities include over 50 behavioral assays that can be applied to any disease. We offer 30+ disease models and unmatched surgical expertise for manipulations, dosing directly into the CNS space and placement of implants and cannula.

Biomarker Analysis

PsychoGenics has developed extensive biomarker analysis capabilities so you can keep your project under one roof. Our expert biomarker services deliver quality data and simplify your project.

Drug Abuse Liability

The ability to detect or refute drug abuse liability is critical in drug development, licensing, and postmarketing surveillance. PsychoGenics has been validating and applying rodent models of drug abuse liability for over a decade.

EEG Studies

EEG is a highly translational biomarker, and our deep understanding of baseline signals and variability are critical to properly analyzing your data. With expert surgical implantation capabilities and industry-leading models, the quality of your data is assured.

Electrophysiology

PsychoGenics’ electrophysiological expertise and commitment to study customization allow us to conduct challenging experiments.

Histology and Immunohistochemistry (IHC)

Our dedicated team of scientists tailor staining methodologies to align with each distinct project. Specializing in CNS IHC, we ensure data relevance for the designated region of interest (ROI).

Microdialysis

Our microdialysis expertise encompasses both single and dual probe studies. A seasoned surgical team ensures precision in cannula placement, while our in-house analysis offers quantification of drug exposure and neurochemicals.

Pharmacokinetics and Pharmacodynamics (PK and PD)

Our comprehensive preclinical PK and biomarker assessment combine our in vivo dosing and tissue sampling, and expertise with a suite of analytical platforms to determine associations between the drug exposure required for behavioral efficacy and changes in your biomarker(s) of interest.

Receptor Occupancy

With our pharmacological expertise and state-of-the-art equipment that includes a digital real-time autoradiography (BeaQuant; www.ai4r.com), we can detect target engagement even poorly expressed targets.