In recognition of Huntington’s Disease (HD) Awareness Month, PsychoGenics is proud to support your HD research needs.
With decades of experience in HD research, we offer three, fully characterized, mouse models of HD for assessing potential therapeutics: the zQ175 knock-in (replacement of mouse Huntingtin (HTT) exon 1 with the mutant human HTT exon 1, 190 CAG repeats), the R6/2 120 CAG (expresses the N-terminal portion of the huntingtin protein), and the R6/1 (carries the human huntingtin gene’s 5’ end, 116-120 CAG repeats).
Through molecular, behavioral, histological, and electrophysiological approaches, we have characterized these models at both pre-and post-symptomatic stages. These models serve as validated and predictive tools for assessing novel HD treatments.