Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-linked methyl CpG binding protein 2 (Mecp2) gene. Primarily affecting girls, it stands as a leading cause of intellectual disabilities. Preclinical studies of Rett syndrome are pivotal for advancing treatment development. Our team brings extensive preclinical research experience to support you in discovering the next therapeutic breakthrough for Rett syndrome.
Mecp2 Mouse Model of Rett Syndrome mode of Rett Syndrome
The Mecp2 mouse model closely mirrors the symptoms and progression of Rett syndrome. While male Mecp2 mice exhibit poor health and a short life span, female Mecp2 mice demonstrate normal survival, but show changes in motor function, startle response, respiration, visual acuity, and electrographic seizures, thus enabling us to screen novel therapeutics.
Driving Your Preclinical Rett Syndrome Research Forward
At PsychoGenics, we collaborate closely with the leading researchers in Rett syndrome research, harnessing the power of the Mecp2 heterozygous knockout mouse model to explore the underlying mechanisms of Rett syndrome and give you the best opportunity to discover your breakthrough.
Our neurodevelopmental disorders areas of expertise: