PsychoGenics is dedicated to supporting your research and advancing your program with tailored preclinical Angelman syndrome studies.
Angelman syndrome is a neurodevelopmental disorder that emerges early in life, marked by developmental delays, intellectual challenges, and specific behavioral features.
Ube3a Het Mouse Model
PsychoGenics has experience with a heterozygous Ube3a Het knockout mouse model of Angelman Syndrome, which shows similar genotypic and phenotypic characteristics as the human condition, providing insights crucial for the development of effective treatments.
By closely studying the progression of Angelman syndrome in Ube3a Het mouse neonates, and applying our EEG expertise to measure brainwave patterns, we offer valuable insights that can inform the development of your treatment.
Time spent in W, NREM and REM in the Light and Dark Phases
During the light phase, Ube3a Het mice spent less time awake and more time in NREM and REM sleep compared to WT littermates.
During the dark phase, Ube3a Het mice spent more time awake and less time in NREM and REM sleep compared to WT littermates.
Aberrant Waveforms
Ube3a Het mice have multiple seizure types. Three types are reported on here. The top panel represents the expression across the 12/12 hour light/dark cycle of one seizure type labeled “SS”. SS is a non-motor seizure that is found only during waking and is seen in both the frontal and parietal channels. The expression of SS has little variation across the light/dark cycle. The middle panel represents the expression another seizure type labeled “WS”. WS is also a non-motor seizure that is found only during waking but is seen only in the frontal channel. WS occurs more during the dark phase compared to the light phase. The bottom panel represents the expression another seizure type labeled “RS”. RS is also a non-motor seizure that is found only during REM sleep and, like WS, is seen only in the frontal channel. RS occurs more during the light phase compared to the dark phase.
Utilizing EEG in Preclinical Angelman Syndrome Studies
Electroencephalography (EEG) can play an important role in preclinical Angelman syndrome studies, and our team recognizes the immense value of the EEG as a powerful translational tool for assessing sleep/wake patterns and detecting abnormal EEG patterns associated with the disorder.
Identifying Early Onset Symptoms
At PsychoGenics, our phenotypic characterization of the Ube3a mouse model of Angelman Syndrome demonstrates a robust deficit in neonatal ultrasonic vocalization and gait impairment in adulthood.
Advancing Your Preclinical Angelman Syndrome Research
Through continued dedication, innovative research methodologies, and collaboration, PsychoGenics strives to propel your research program forward, contributing to meaningful advancements in the Angelman syndrome research community.
Our neurodevelopmental disorders areas of expertise: