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68 Results for Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

...presentation describing the TDP43 Mouse Model of ALS. Read More Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain...

Amyotrophic Lateral Sclerosis Models SOD1G93A

1Confidential Amyotrophic Lateral Sclerosis Models SOD1G93A 2Confidential page 2 SOD-1 (G93A) Mouse Model • Amyotrophic Lateral Sclerosis (ALS) is a progressive paralytic disorder marked by the degeneration of motor neurons...

Amyotrophic Lateral Sclerosis Models TDP43

1Confidential Amyotrophic Lateral Sclerosis Models TDP43 2Confidential Walker et al., 2015 Introduction • It is estimated that ~97 % of ALS patients display a common phenotype in disease-affected tissues, namely...

Epilepsy and Seizure

...is a presentation describing the Preclinical Models of Seizure and Tremor in Mice capabilities at PsychoGenics. Read More Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders...

Epilepsy and Seizure

...recurrent seizures with clear spike trains and are sensitive to potential AEDs. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s...

Epilepsy and Seizures

...recurrent seizures with clear spike trains and are sensitive to potential AEDs. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s...

SOD1 Mouse Model of ALS

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

TDP43 Mouse Model of ALS

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Rett Syndrome

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

APP/PS1 Amyloidosis Mouse Model of Alzheimer’s Disease

...a deficit in APP/PS1 mice. (B) Summary of data taken from the last 5 minutes of recordings.*p<0.05 compared to WT mice. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Microdialysis Studies (PK/PD)

...dopamine levels. Sprague Dawley rats, male, 250-300g, n=10/group. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine...

Push-Pull Microdialysis

...standard curves and presented as percentage of baseline (amount at time 0). Phospho Tau to Total Tau ratio is also presented (c). Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia...

Standard Microdialysis Technique

...Therapeutics September 2016, 358 (3) 472-482. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models...

A Field Guide to Huntington’s Mouse Models

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Gaucher’s Disease

...treated mice. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular Dystrophy Parkinson′s Disease...

Preclinical Models of Seizure and Tremor in Mice

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Depression & Sexual Function

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Pain

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Tg4510 Tauopathy Mouse Model – Inducible Expression of hTau (P301L) in Alzheimer’s Disease

...activation as seen by additional ramification, somal growth and increased cell density (cytosis). Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model)...

120 CAG R6/2 Mouse Model of Huntington’s Disease

...our additional resources: https://www.psychogenics.com/services/huntington%e2%80%b2s-disease/ https://chdifoundation.org/a-field-guide-to-working-with-mouse-models-of-huntingtons-disease.   Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models...

Auditory Evoked Potentials

...prior to MMN, respectively. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular Dystrophy...

ASD and Neurodevelopment Disorders

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Drug Abuse Liability

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Brain & Spine Injury Models

...therapies to promote brain plasticity in order to restore function continue to require preclinical testing. Read More Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile...

Combined measures (PK/PD)

...SFN Meeting 2016, Poster 217.16/G29 Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular...

Asyn Fibrils

...Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular Dystrophy Parkinson′s Disease Rett Syndrome...

Anxiety

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Phenotypic Analysis of zQ175 (neo+) and zQ175DN (delta neo) Heterozygous and Homozygous Knock-In Mouse Model

...A; p<0.001 for panel B). (Figures adapted from Beaumont, V. et al (2016) Neuron.) Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse...

Immunohistochemistry

...4′,6-diamidino-2-phenylindole. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular Dystrophy Parkinson′s Disease Rett...

In Vivo Electrophysiology

Home » You searched for Amyotrophic Lateral Sclerosis Single-unit, Multiunit, And Local Field Potential Recording In Anesthetized Rodents In vivo electrophysiology measures neuronal activity in the brain as either local...

Motor Function

...Treadmill can be used to force exercise animals at regular interval or to collect endurance data like distance traveled total or at a particular speed, number of rests. Amyotrophic Lateral...

Parkinson′s Disease

...Parkinson’s Disease: Validated Non-Genetic Animal Models This is a presentation describing the Parkinsons capabilities at PsychoGenics. Read More Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders...

Retrodialysis

...administered drugs. Subsequently we are able to analyze neurotransmitters in situ in the same brain region or in a different brain nuclei using double probe microdialysis. Amyotrophic Lateral Sclerosis Alzheimer’s...

Fragile X (FMR1 Mouse Model)

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Luminex®

...time dependent increase of cytokines production in the mouse serum following LPS (3mg/kg, i.p) treatment. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1...

Parkinson’s Disease: Validated Non-Genetic Animal Models

...dopamine transporter (DAT) 180 days after injection of αSyn fibrils; [*-Significantly different, P<0.05, unpaired t-test]. Luk et al., Science 2012. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and...

Line 61

...14-month-old Line 61 mouse. Note strong expression in the nigrostriatal path. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease...

Quantification of Phosphoproteins and Secondary Messengers

...lane corresponds to a single animal) or ELISA (Bottom Panel). Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain...

Alzheimer’s Disease and Frontotemporal Dementia

...APP/PS1 Amyloidosis Mouse Model of Alzheimer’s Disease. Read More Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain &...

Huntington′s Disease

...PsychoGenics' work in phenotypic analysis of zQ175 (neo+) and zQ175DN (delta neo) Heterozygous and Homozygous Knock-In Mouse Models of Huntington's disease. Read More Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal...

Muscular Dystrophy

...mice exhibited greater fatigue than WT control mice. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine...

Spinal Muscular Atrophy

Home » You searched for Amyotrophic Lateral Sclerosis Spinal muscular atrophy (SMA) is a rare autosomal recessive motor neurodegenerative disease and is the leading genetic cause of death among infants...

Cognition and Motivation

...task using reversal paradigm in which the platform is moved to the opposite end of the tank. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile...

Schizophrenia & Mania

...progression of neuropathology associated with cognitive impairment that can be reversed by suppression of transgene expression following chronic treatment with Doxycycline. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Pharmacokinetics/Exogenous Molecules

...over a 7 hour time course. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models...

Samples and Sectioning

...this case all parts of the spinal cord can be evaluated on one section. Figure 2: USR protocols for large (upper) and small (lower) samples. Amyotrophic Lateral Sclerosis Alzheimer’s Disease...

Imaging

...Figure 1: microscopy equipment. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular Dystrophy...

Qualitative Histology

...samples at different Bregma levels. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular...

Receptor Autoradiography

...occupancy at the α4β2 nAChRs (~40% and ~90% respectively). Data published in: Psychopharmacology (Berl). (2011) 217(2): 199-210. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile...

Quantitative RT–PCR

...Feb 1;83:40-50. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular Dystrophy Parkinson′s Disease...

Quantitative Western Blot

...housekeeping protein, was detected by direct fluores cence with rhodamine-conjugated GAPDH antibody. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s...

Rodent Primary Neurons and Glia Culture

...Imaging was performed on a Zeiss AXIO Imager A1 with a conjoining AxioCAM MRc5 and visualized using a 20 X objective. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD...

Glucose Metabolism [14C-2-Deoxyglucose (14C-2-DG)]

...atypical antipsychotics, like Clozapine, is thought to result from blockade of dopamine, serotonin, muscarinic, and adrenergic neurotransmission. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile...

ELISA / Luminex®

...Molecule Array (SIMOA) bead technology allowing measurement of low-abundance biomarkers. Read More Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s...

Slice Electrophysiology

...block by APV. D, Normalized I-V relationship for the cortically evoked NMDA EPSC exhibits a characteristic negative slope conductance at negative potentials (n=14). Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal...

Sleep-Wake Polysomnographic EEG

...state. *p<0.05 [(t-test)]. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular Dystrophy Parkinson′s...

Animal Models of Alzheimer’s Disease rTg4510, An Inducible Tauopathy Mouse Model, Expressing Human P301L-Mutant Tau In the Forebrain

...weeks of age. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular Dystrophy Parkinson′s...

Preclinical Models of Spinal Cord Injury

...(**p<0.01). Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular Dystrophy Parkinson′s Disease Rett...

Preclinical Models of Traumatic Brain Injury

...and NeuN (green) reveals neuronal loss in CA3 region of hippocampus following neurotrauma (arrowheads in C vs. D). Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders...

Quantitative Histology

...counted. This count related to ROI size estimates the cell destiny very precisely. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model)...

Biometric Monitoring

...6 hours during the day (lights on). Note that the rapid results calculated from the PiezoSleep system is consistent with manual sleep-scoring. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia...

ELISA

...represent statistical comparison against tTA vehicle group [ns, not significant; ****, p≤0.0001]. Bracket indicate comparison between rTg4510 vehicle and rTg4510 doxycycline groups [####, p≤0.0001]. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and...

Quanterix SIMOA Technology

...elevated in a knock-in mouse model of Huntington’s disease, Q175KI Het, at 61-63 weeks of age. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X...

Endogenous Molecules

...to but above the LLOQ. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s Disease Brain & Spine Injury Models Muscular...

Autoradiography Services

...vivo & ex vivo receptor occupancy (RO) offers a simple yet powerful way to measure compound/target engagement using a selective radioligand and receptor autoradiography. Read More Amyotrophic Lateral Sclerosis Alzheimer’s...

In Vivo and Ex Vivo Receptor Occupancy

...the α4β2 nAChRs (~40% and ~90% respectively). Data published in: Psychopharmacology (Berl). (2011) 217(2): 199-210. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1...

Functional G-Protein-Coupled Receptor (GPCR) Activation Assay (35SGTPγS Binding)

...about 104% for spinal cord, 89% for striatum/accumbens, and 72% for amygdala. Amyotrophic Lateral Sclerosis Alzheimer’s Disease and Frontotemporal Dementia ASD and Neurodevelopment Disorders Fragile X (FMR1 Mouse Model) Huntington′s...

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

...of etiology-specific therapy of epilepsy is treatment of patients with tuberous sclerosis complex (TSC) with everolimus, a drug that allosterically inhibits the mechanistic target of rapamycin (mTOR) pathway (Ostendorf and...