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9 Results for Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis Models SOD1G93A

1Confidential Amyotrophic Lateral Sclerosis Models SOD1G93A 2Confidential page 2 SOD-1 (G93A) Mouse Model • Amyotrophic Lateral Sclerosis (ALS) is a progressive paralytic disorder marked by the degeneration of motor neurons...

Amyotrophic Lateral Sclerosis Models TDP43

1Confidential Amyotrophic Lateral Sclerosis Models TDP43 2Confidential Walker et al., 2015 Introduction • It is estimated that ~97 % of ALS patients display a common phenotype in disease-affected tissues, namely...

Amyotrophic Lateral Sclerosis

SOD1 Mouse Model of ALS This is a presentation describing the phenotype of the SOD1 (G93A) Mouse Model of ALS. Read More TDP43 Mouse Model of ALS This is a...

Epilepsy and Seizure

...sharp waves, paroxysmal spike-and-wave activity, slow waves, and spike bursts or trains.   Tuberous Sclerosis Work funded by the Tuberous Sclerosis Alliance (TSA) on behalf of the TSC Preclinical Consortium...

Epilepsy and Seizures

...spike-and-wave activity, slow waves, and spike bursts or trains. Tuberous Sclerosis Work funded by the Tuberous Sclerosis Alliance (TSA) on behalf of the TSC Preclinical Consortium has enabled prioritization of potential...

Epilepsy and Seizure

...activity, slow waves, and spike bursts or trains.   Tuberous Sclerosis Work funded by the Tuberous Sclerosis Alliance (TSA) on behalf of the TSC Preclinical Consortium has enabled prioritization of potential...

SOD1 Mouse Model of ALS

Neurofibrillary tangles and amyloid plaques are widely thought to play a major role in development of Alzheimer’s disease (AD) pathology. The rTg4510 mouse is a mouse model of tauopathy overexpressing...

TDP43 Mouse Model of ALS

Neurofibrillary tangles and amyloid plaques are widely thought to play a major role in development of Alzheimer’s disease (AD) pathology. The rTg4510 mouse is a mouse model of tauopathy overexpressing...

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

...of etiology-specific therapy of epilepsy is treatment of patients with tuberous sclerosis complex (TSC) with everolimus, a drug that allosterically inhibits the mechanistic target of rapamycin (mTOR) pathway (Ostendorf and...