Comparison of Pentameric Formyl Thiophene Acetic Acid (pFTAA) staining in humans and animal models of disease
Spinal cord injury (SCI) is a debilitating condition that significantly impacts the quality of life. Incomplete tetraplegia, resulting from cervical spinal cord lesions, is the most common SCI type and…
Neurofilament-light chain protein (NF-L), a biomarker of axon degeneration and neuron death
NF-L is a validated biomarker for assessing disease progression, intensity, and treatment response across a wide range of neurodegenerative disorders...
Characterization of a Mouse Model of Parkinson’s Disease
The Thy-1-α-synuclein mouse model of Parkinson’s disease is a transgenic mouse model that over-expresses wild-type human alpha-synuclein under the Thy1...
The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models
Heterozygous mutations in the GBA1 gene – encoding lysosomal glucocerebrosidase (GCase) – are the most common genetic risk factors for...
Phenotypic characterization of recessive gene knockout rat models of Parkinson’s disease
Kuldip D. Dave, Shehan De Silv, Niketa P. Sheth, Sylvie Ramboz, Melissa J. Beck, Changyu Quang, Robert C. Switzer III,...