Fragile X Syndrome (FXS) is a genetic disorder caused by a CGG expansion in the Fmr1 gene. This condition tends to affect males more severely, while females often present a mosaic pattern of effects. Symptoms of FXS include: delayed crawling and walking, speech delays, hyperactivity & impulsivity, and cognitive deficits.
Mice with a knockout allele of the Fmr1 gene on the X chromosome exhibit phenotypic characteristics of FXS in humans. Male Fmr1 knockout mice, particularly those bred on an FVB/n background at PsychoGenics, are a valuable tool for exploring the mechanisms of Fragile X syndrome.
Increased Locomotor Activity
