Preclinical In Vivo Electrophysiology Services

Preclinical In Vivo Electrophysiology Services

Single-Unit, Multi-Unit, and Local Field Potential Recording

Preclinical in vivo electrophysiology services utilizing fully intact models deliver a powerful advantage in the accurate assessment of your compound: translational power. PsychoGenics is one of the few organizations that can perform these challenging studies, and our frontline scientists deliver actionable data as a matter of course. 

Our reputation in this area is exemplary.

Tap the translational power of preclinical in vivo electrophysiology with our unmatched disease model offerings and unparalleled preclinical know-how. 

PsychoGenics enables you to investigate the functionality and interconnectivity of neurons in living organisms, yielding valuable insights into the changes in firing patterns observed in genetically modified animals. Additionally, this approach allows evaluation of the impact of potential drug candidates on these altered pathways. 

The concurrent application of stimulation and recording techniques further aids in uncovering how a candidate drug can either inhibit or activate specific neural pathways, thereby providing a deeper understanding of its therapeutic effects. 

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PsychoGenics’ skilled scientists provide expert microiontophoresis services to examine the effects of locally administrated compounds on neuronal firing. This technique involves using a glass micropipette to precisely deliver drugs in very small amounts to specific brain regions by applying a voltage across the micropipette and causing the electrode to become polarized. 

The ionized particles in the solution then migrate and are ejected from the tip. Microiontophoresis has experimental, therapeutic, and diagnostic applications in preclinical research and is especially useful for studying CNS effects of drugs that do not cross the blood barrier.

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In vivo recordings combined with blood collection at multiple time points can be useful to:

  1. Understand how the body processes a drug and how its concentration changes during recording (PK)
  2. Provides a functional consequence of target and pathway engagement (PD)

This correlation enables accurate prediction of the clinical response in human subjects.

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