Depression & Sexual Function – Tail Suspension
Mice that are suspended by their tails become motionless, similar to the immobility behaviors exhibited in the forced swim test. A large variety of clinically active typical and atypical antidepressants reduces this immobility.
Pretreatment with desipramine (5, 10, and 20 mg/kg; i.p.) significantly decreases time immobile in 129SVEV (top), C57BL/6J (middle) and DBA/2J (bottom) mice.
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Pretreatment with desipramine (20 mg/kg; i.p.), DOV-21947 (20 mg/kg; i.p.) and venlafaxine (10, 20, and 30 mg/kg; i.p.) decrease immobility in 129SVEV mice.
Pretreatment with desipramine (20 mg/kg; i.p.), buproprion (20 mg/kg; i.p.), and fluoxetine (20 mg/kg; i.p.), significantly decrease time immobile in A/J mice.
