Microdialysis Studies (PK/PD)
UPLC-MS/MS bioanalysis offers the option of performing analysis of both endogenous and exogenous molecules in one injection ultimately providing PK/PD data to track the drug impact on a biomarker of interest.
A ketamine dose-response study on extracellular ketamine and dopamine levels in microdialysates collected from striatum of freely moving rats. Ketamine levels as anticipated correlate with the initiation of increasing dopamine levels. Sprague Dawley rats, male, 250-300g, n=10/group.