by Desiree Cobb-Olori | Mar 27, 2025
Daniel Havas, Kristina Locker-Kovacovicova, Smriti Mongia Objective: Histological detection of amyloids in human and mouse brain tissue is complex. Fibril structures and aggregation lead to a reduction of relevant epitopes for primary antibody detection and some...
by Desiree Cobb-Olori | Feb 6, 2025
NF-L is a validated biomarker for assessing disease progression, intensity, and treatment response across a wide range of neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis...
by Desiree Cobb-Olori | Apr 18, 2024
The Thy-1-α-synuclein mouse model of Parkinson’s disease is a transgenic mouse model that over-expresses wild-type human alpha-synuclein under the Thy1 promoter in neurons. The model exhibits dopaminergic neuronal loss, alpha-synuclein aggregates, neuroinflammation,...
