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F. BALCI, A. ROONEY, S. M. OAKESHOTT, M. DAY, D. BRUNNER

Huntington’s disease (HD) is an autosomal dominant disorder characterized by corticostriatal dysfunction and degeneration of the striatum with progressive loss of the medium spiny neurons. These circuits are important for interval timing and temporal control over motor output. We investigated the acquisition of peak responding in R6/2 mouse model of Huntington’s disease and their corresponding wild type controls. R6/2 acquired the termination of an ongoing response after the reinforcement time later than the WT mice. While R6/2 and WT mice did not exhibit differences in temporal accuracy post-acquisition response curves were flatter in R6/2 mice. The results are discussed in terms of the neurobiology of interval timing, pathophysiology of Huntington Disorder and R6/2 mice.