Select Page
Genetic knockdown of HDAC4, or sub-chronic treatment with a novel selective Class IIa HDAC inhibitor, reverses elevated membrane excitability in striatal medium spiny neurons from R6/2 and zQ175 Huntington’s disease model mice

Genetic knockdown of HDAC4, or sub-chronic treatment with a novel selective Class IIa HDAC inhibitor, reverses elevated membrane excitability in striatal medium spiny neurons from R6/2 and zQ175 Huntington’s disease model mice

G. C. TOMBAUGH, S. GELMAN, A. BRADAIA, K. WADEL, V. GARDES, C. TOULLER, A. SERS, A. GHAVAMI, B. BUISSON, G. BATES, M. MIELCAREK, C. DOMINGUEZ, M. MAILLARD, V. BEAUMONT Huntington’s disease (HD) is a lethal autosomal dominant neurodegenerative disorder that leads...