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Rational Design and Development of Drugs for the Treatment of Depression through Partial Agonism and Desensitization of 4β2-Nicotinic Acetylcholine Receptors (nAChR): A Multi-disciplinary and Collaborative Approach

J. B.EATON, HAN-KUN ZHANG, LI YU, T HANANIA, E SABATH, A FEDOLAK, L LUCERO, D BRUNNER, A. P. KOZIKIWSKI, R. J. LUKAS Depression is among the most common and debilitating symptoms of psychiatric disorders and has thus been the subject of extensive scientific study....