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Teamwork, Excellence, Creativity and Entrepreneurial Spirit

At PsychoGenics we value teamwork, excellence, creativity and entrepreneurial drive. We are excited about our mission and endeavor each day to build a company that fosters that excitement. We believe that our employees are our most important and valued asset and we are committed to the creation of a working environment that encourages each employee’s professional and personal development. We believe in rewarding the efforts of our employees through competitive compensation and a comprehensive benefits plan.

Job Openings

Computational Biologist

In this role, candidate will work with a multidisciplinary team to design, develop & create analytical solutions through applications of Data Mining, Machine Learning and Artificial Intelligence.

Overview of Position:

Data scientist, with expertise in drug discovery, machine learning particularly deep learning, computer vision and data analysis of high-dimensional data.

Key Responsibilities:

  • Analyze large datasets using machine learning techniques and translate insights into prioritizing compounds with desired indications
  • Work with medicinal chemists to develop computational tools for the calculation, visualization and analysis of relevant drug design ADME, pharmacokinetic and pharmacodynamic endpoints
  • Develop and evaluate novel machine learning algorithms for computer vision including object detection, segmentation and behavior assessment
  • Handling and analysis of high-dimensional experimental data
  • Improve upon existing computational methods
  • Provide data analysis support to other divisions in the company
  • Work with software developers to integrate new algorithms into prototype and production systems

Required Qualifications:

  • PhD in Computational biology, Computer Science, Data Sciences or related fields with at least 2 years of experience in development/data analysis
  • Fluency in high-level programming and scripting languages (MATLAB, Python)
  • Experience with machine learning methods such as deep learning, SVM, decision tree
  • Strong statistical and analytical skills
  • Experience developing algorithms for high dimension data
  • Ability to work independently and present data to a multidisciplinary audience in a clear and cohesive manner
  • Excellent teamwork, time management and organizational skills
  • Excellent verbal and written communication skills

Preferred Qualifications:

  • Experience in Computational biology or Bioinformatics
  • Working knowledge in Drug Discovery and Chemo-informatics
  • Experience with high-throughput biological data analysis
  • Experience developing software in a team environment
  • Experience mining various database such as ChEMBL to extract relevant information for building models for QSAR and target inhibition
  • Experience with C++ and/or C#
  • Experience with CUDA GPU development
  • Experience with machine learning frameworks such as TensorFlow and/or PyTorch
  • Familiarity with source control systems such as SVN
  • Familiarity with object-oriented patterns and development practices

To apply for the position please send your resume to Mukesh Bansal



Scientist/Principal Scientist, Translational EEG

Overview of Position:

Design, develop, and perform in-vivo rodent EEG/LFP studies including stereotaxic surgery, EEG recordings, and data analysis, statistics and preparation of written reports.

Key Responsibilities:

  • Design, develop, and perform experiments to analyze EEG pattern changes induced by pharmaceutical agents, gene KO/expression, seizure, and/or sleep
  • Perform the in-life portion of the studies, including surgeries, dosing, and EEG recordings
  • Compile and analyze EEG data, including sleep-scoring, seizure detection and spectral analysis
  • Develop clear visualizations to convey complicated data in a straightforward fashion, write study plans and reports

Required Qualifications:

  • MS/PHD in Neuroscience, Biomedical Engineering, or related degree
  • Animal handling with experience in dosing, IP, PO, SC, and IV
  • Compound formulations and dilutions
  • Stereotaxic surgery, including pre and post-op care
  • Electrophysiological recordings, including EEG with auditory evoked potentials, sleep and spectral changes
  • EEG sleep and spectral analysis

Preferred Qualifications:

  • EEG analysis expert
  • Knowledge of electronics and EEG recording systems (DSI, Spike2, Pinnacle)
  • Expertise in rodent EEG analyses including signal processing, sleep scoring, and seizure detection.
  • Programming experience (i.e. Matlab, EEGLAB, Python, R and/or statistical software like JMP)
  • Previous experience in performing rodent EEG surgery and recordings

To apply for the position please send your resume to Rebecca Buonadies



Pharmacology and Formulation Associate / Sr. Associate

Overview of Position:

Provide oversight and management of PsychoGenics (PGI) controlled substance program. Lead for pharmacology and formulation of compounds in support of research. Execute quality control of associated procedures. Interface with IT in implementing applications for the data manager (DM). Train PGI staff on the drug manager registration and tracking of drug in the DM. Assure compliance with guidelines of the Drug Enforcement Agency (DEA), Food and Drug Administration (FDA), Occupational Safety and Health Administration (OSHA), and other government agencies as applicable. Write, edit, review, comprehend and comply with all SOP's and IACUC, safety and quality assurance standards related to assigned work area.

Key Responsibilities:

    1.  Controlled Substance Officer:
    1. Management and oversight of the controlled substance program including receipt of controlled substances and implementing primary controls.
    2. Assist in dispensing drug daughter vials to secondary handlers to meet in-house orders in support of research, and to verify DM records of use and collection of waste.
    3. Maintain controlled substance inventory and record keeping including integration with the company Chemical Registration database.
    4. Prepare DEA Biennial Inventory reports, and PGI annual inventory reports.
    5. Train new employees on controlled substance procedures and confirm verification of completion of required training and background checks prior to providing controlled substance privileges. Ensure that staff with access to controlled substance pharmaceutical cabinets are properly trained to handle and maintain accurate controlled substance records in the DM.
    6. Conduct controlled substance audits and perform monthly pharmaceutical box waste collections and as needed.
    7. Manage controlled substance waste destruction at least annually and as needed. Quality Control current controlled substance records and inventory of waste for newly collected waste. Schedule waste pick-ups and prepare all required documentation for the controlled substance waste destruction.
    8. Work with the DEA on controlled substance unannounced site audits.

    2.  Pharmacology and Formulation:
    1. Formulation of compounds assessing drug solubility to include compound weighing, preparing dilutions working with approved solvents and vehicle cocktails, use of apparatus for sonication (water bath and probe), vortex, pH adjustment, labeling, coding, and de-coding drug.
    2. Perform drug calculations for preparations in support of research.
    3. Quality Control check of drug sheets, client notebooks, and DM entry.
    4. Conduct new hire training sessions in DM use, controlled substances, wet lab procedures, and safety orientation maintaining DM training records. Technical training procedures performed include formulation, and proper use of wet lab apparatus and equipment used in preparation of drug for delivery to animals.
    5. Interface with IT in implementing applications for the DM, trouble shoot and correct any identified errors or incorrect entry by users.

    3.  BioSafety OCHS Team:
    1. Support team in OCHS assessment of work area.
    2. Provide hazard assessment of drug or agents to be used in the facility.
    3. Preparation and update of BioSafety Addendums and associated SOPs in support of any identified hazards including SOP tracking and integration in DM.
    4. Perform inspections of wet lab areas.

Required Qualifications:

Bachelor’s degree in biological science preferably related to biochemistry, or a related field with a minimum of 6 years’ experience or a Master’s degree with at least 4 years relevant experience. Experience preferred including controlled substance handling and proficiency in formulations of new chemical entities. Detail oriented, organizational and multi-tasking skills required. Have an ability to work both independently and under direct supervision. Demonstrate solid communication skills and leadership qualities as well as a strong team player. Willingness to work in a dynamic environment, with potential overtime work required to accomplish all tasks of this position. Working experience with Microsoft Windows, Excel, and Word is required.

Preferred Qualifications:

Familiarity with federal regulations governing live animal research including but not limited to USDA, AAALACi, PHS OLAW, the ‘Guide’, IACUC, GLPs, and SOPs.

To apply for the position please send your resume to Rebecca Buonadies



Principal Scientist / Senior Principal Scientist Medicinal Chemistry, Drug Discovery

About PsychoGenics

PsychoGenics is a well-established preclinical Contract Research Organization (CRO) that provides comprehensive preclinical testing capabilities in CNS and orphan disorders. PsychoGenics has established several automated behavioral platforms, including the SmartCube® platform that provide phenotypic screening at an industrial level to support drug discovery programs. The Company is establishing a drug discovery group to exploit their technology platforms and is seeking to hire medicinal chemists at the Principal Scientist/Senior Principal Scientist level. The appointees will report to the Vice President of Medicinal Chemistry.

Overview of Position:

The successful applicants will be accomplished medicinal chemists, with a proven track record, and who can develop and lead drug discovery projects at PsychoGenics, with a focus on developing new small-molecule therapies for CNS disorders. Candidates will be expected to have strong technical and problem-solving skills in medicinal chemistry with expertise in the use of computational drug design to aid drug discovery. Proven experience of successful “hands on” chemistry in the laboratory, managing chemistry outsourcing, and a deep understanding of pharmacokinetic and drug metabolism studies, biology and pharmacology, will be expected. With good interpersonal skills, the successful applicants will take a leading role in interactions with collaborators, both within existing projects and in developing new research programs. Exceptional written and oral communication skills, interpersonal skills and critical thinking skills will be required.

Key Responsibilities:

  • Act as chemistry project leader for PsychoGenics CNS projects with the goal to identify novel pre-clinical candidates
  • Through both “hands on” laboratory chemistry and the use of external vendors (CRO’s), identify hit compounds and optimize them for in vitro, in vivo and toxicological properties
  • Use computationally assisted drug design (CADD) techniques to guide lead optimization studies
  • Interact closely with key collaborators both internally and externally including biologists, pharmacologists, drug discovery and development organizations and develop and manage relationships with collaborators and partners
  • Contribute to the dissemination of research results in the form of presentations at internal drug discovery meetings and external meetings
  • Assist the VP with the management of additional PsychoGenics research programs, initiatives and projects
  • Assist in growing the newly established drug discovery group at PsychoGenics

Qualifications:

  • Ph.D. in chemistry or medicinal chemistry with 5-10 years or more postdoctoral experience in biotech or the pharmaceutical industry with a focus on small molecule drug discovery
  • Proven track record of medicinal chemistry and drug discovery to identify pre-clinical candidates and documented in the form of publications
  • Familiar with the use of phenotypic screening in drug discovery
  • Creative and scientifically-oriented and who continually keeps up to date with the literature to keep abreast of new methods and techniques
  • Excellent verbal and written communication and interpersonal skills
  • Demonstrated ability to work effectively within a team and with external partners

To apply for the position please send your resume to Rebecca Buonadies



Senior Biologist, Drug Discovery

A highly motivated biologist with extensive experience leading drug discovery and development efforts for CNS programs through close collaboration with others.

Key Responsibilities:

  • Provide biological strategy and strong scientific, technical, and organizational leadership to drive drug discovery and development efforts supporting selected CNS projects
  • Oversee biological study designs and execution, data analysis and report writing
  • Participate in a multi-disciplinary team of biologists and chemists to progress programs
  • Stay abreast of the latest scientific and competitive developments and apply knowledge to project strategy
  • Prepare and present hypotheses, on-going progress reports, technical reports and future planning (including contributing to budgets and business plans)
  • Contribute to building a culture that embraces scientific excellence and integrity with a sense of urgency and collaboration with key stakeholders
  • Assume project responsibilities and effectively present updates to the senior leadership team

Qualifications:

  • Ph.D. in biochemistry, cell biology, pharmacology or a related scientific field
  • 5+ years of experience in CNS drug discovery in a pharmaceutical and/or biotech environment
  • Experience working with cross-functional teams
  • Familiarity with the preclinical regulatory requirements for small molecule development
  • Excellent communication skills with the proven ability to work effectively as a member of a multidisciplinary team
  • Excellent interpersonal skills and the desire to succeed in a collaborative work environment

To apply for the position please send your resume to Rebecca Buonadies



Research Associate 1 - Behavioral Pharmacology

We are looking for a highly motivated Research Associate in behavioral neuroscience. The successful candidate will work in a team of scientists and researchers supporting the preclinical studies using rodent models and tests. The primary responsibilities of the candidate will include but are not limited to conducting preclinical research of drug abuse liability, pain, cognition, and other assays as needed. The candidate must be capable of working across teams and independently.

Key Responsibilities:

  • Execution of rodent studies in behavioral pharmacology pain assays
  • Preliminary experimental data analysis

Qualifications:

  • A Bachelors degree in life sciences, neuroscience, or psychology with 1+ years of laboratory and behavioral experience with rats and/or mice
  • Experience with a variety of behavioral tests with rats and mice, including operant conditioning based experiments preferred
  • Able to work well in a group atmosphere as well as independently
  • Good organization and troubleshooting skills
  • High level of commitment, excellent motivation to perform and to learn
  • Able to comprehend and comply with all SOP and IACUC, safety and quality assurance protocols
  • Computer skills on Microsoft Office and statistical software

To apply for the position please send your resume to Rebecca Buonadies



Research Associate – Immunohistochemistry

Key Responsibilities:

  • Conduct laboratory projects from embedding to sectioning, labeling to imaging
  • Conduct laboratory projects in different departments
  • Work with samples which will be of animal and human origin
  • Embed, prepare and analyze biological tissue samples
  • Tissue cutting
  • Do histochemical stainings, immunohistochemistry
  • Do imaging and image analysis
  • Work with standard histological equipment such as cryostats; microtomes, microscopes and digital slide scanner
  • Place laboratory orders

Qualifications:

  • Bachelor’s degree in Biological Sciences required
  • 2 + years’ experience in IHC and Histology
  • Demonstrated skills including paraffin and/or cryo cutting, handling chemicals, lab math and preparation of solution and dilutions, immuno-histochemical protocols and microscopy
  • Excellent communication skills, organizational skills, and attention to detail

To apply for the position please send your resume to Rebecca Buonadies



Animal Care Technician

Key Responsibilities:

  • Review, comprehend, and comply with all SOPs, IACUC policies, safety, and quality assurance standards related to assigned work area.
  • Daily husbandry of the rodents in the vivarium to include the provision of feed, water, clean cages, and enrichment.
  • Basic sanitation and maintenance of colony rooms to include sweeping and mopping of animal quarters, rotating animal cages, racks and room supplies for cleaning according to schedule, disinfecting all areas in room.
  • Monitor the health of the animals and report any sick or dead to the PVC and room lab contact staff.
  • Receive and house shipments of animals.
  • Bedding sample collection for sentinels; assist with sentinel program procedures as needed.
  • Maintain accurate documentation records as required; including room logs.
  • Monitor room conditions including temperature, humidity, room and rack airflow, and lighting; with timely reporting of any issues to facilities.
  • Maintain adequate PPE, PVC kit, and other common room supplies by monitoring levels, and restocking as required.
  • Monitoring of animal health, and perform procedures such as teeth trims, antibiotic treatments, animal handling, euthanasia, and other simple procedures as certified trained and as required.
  • Ensure availability to work on weekends and holidays as required.
  • Regularly lift up to 50 pounds and move heavy equipment in a safe manner, and have the ability to stand, bend, reach, or crouch while working.

Qualifications:

  • Ability to regularly lift up to 50 pounds and move heavy equipment in a safe manner.
  • Ability to regularly stand, bend, reach, or crouch while working.
  • Strong communication skills interacting with vivarium management and research staff.
  • Availability to work on weekends and holidays as required to maintain compliance in animal care and use, providing oversight of animals 24/7.
  • High school diploma or GED required.
  • Experience in a laboratory animal facility strongly preferred.
  • Achieve ALAT certification after 1 year of employment.

To apply for the position please send your resume to Rebecca Buonadies



Senior Research Associate - Behavioral Pharmacology

We are looking for a highly motivated Senior Research Associate in behavioral neuroscience. The successful candidate will work in a team of scientists and researchers supporting the preclinical studies using rodent models and tests. The primary responsibilities of the candidate will include, but are not limited to conducting preclinical research of drug abuse liability, pain, cognition, and other assays as needed. The candidate will be responsible for surgeries, proper execution of experiments and preliminary data analysis. The candidate must be capable of working across teams and independently.

Key Responsibilities:

  • Execution of rodent studies in behavioral pharmacology, including drug abuse liability studies (such as intravenous self-administration and drug discrimination)
  • Executions of rodent surgeries in relevant studies (especially jugular vein catheter surgery in rats)
  • Preliminary experimental data analysis and draft of study report

Qualifications:

  • A Bachelors or Masters degree in life sciences, neuroscience, or psychology with 5+ years of laboratory and behavioral experience with rats and/or mice
  • Experience with a variety of behavioral tests with rats and mice, including operant conditioning based experiments
  • Surgical skills and dosing experience (IP, SC, PO, etc.)
  • Knowledge of pain assays desirable
  • Able to work well in a group atmosphere as well as independently
  • Good organization and troubleshooting skills
  • High level of commitment, excellent motivation to perform and to learn
  • Able to comprehend and comply with all SOP and IACUC, safety and quality assurance protocols
  • Computer skills on Microsoft Office and statistical software

To apply for the position please send your resume to Rebecca Buonadies



Research Associate 2/ Research Associate 3 - Behavioral Pharmacology

We are looking for a highly motivated Research Associate in behavioral neuroscience. The successful candidate will work in a team of scientists and researchers supporting the preclinical studies using rodent models and tests. The primary responsibilities of the candidate will include but are not limited to conducting preclinical research of drug abuse liability, pain, cognition, and other assays as needed. The candidate will be responsible for surgeries, proper execution of experiments and preliminary data analysis. The candidate must be capable of working across teams and independently.

Key Responsibilities:

  • Execution of rodent studies in behavioral pharmacology pain assays preferred
  • Executions of rodent surgeries in relevant studies (jugular vein catheter surgery in rats a plus)
  • Preliminary experimental data analysis and draft of study report

Qualifications:

  • A Bachelors or Masters degree in life sciences, neuroscience, or psychology with 2+ years of laboratory and behavioral experience with rats and/or mice
  • Experience with a variety of behavioral tests with rats and mice, including operant conditioning based experiments
  • Surgical skills and dosing experience (IP, SC, PO, etc.)
  • Knowledge of pain assays desirable
  • Able to work well in a group atmosphere as well as independently
  • Good organization and troubleshooting skills
  • High level of commitment, excellent motivation to perform and to learn
  • Able to comprehend and comply with all SOP and IACUC, safety and quality assurance protocols
  • Computer skills on Microsoft Office and statistical software

To apply for the position please send your resume to Rebecca Buonadies



Cage Wash Technician

Cage Wash (CW) Technician position in support of PsychoGenics (PGI) vivarium operations. CW tasks are performed in compliance with PGI Animal Care and Use Program Description, according to Animal Welfare regulations, AAALAC International standard, PHS OLAW Assurance, and NJS regulations.

Key Responsibilities:

  • Adhere to and comply with established standard operating procedures related to assigned work area.
  • Maintain cage wash operations in meeting daily workload requirements, to include cleaning and preparing animal cages, providing caging supplies filling cage and caging supply requests, and maintaining other vivarium equipment for use and cleaning processes.
  • Operate cage wash, bottle washer, water filtration systems, autoclave, and floor scrubbing machines properly following safety guidelines.
  • Maintain and sanitize cash wash equipment and machines, cleanliness of cage wash rooms, and cleaning and sanitization of assigned vivarium areas.
  • Maintain adequate personal protective equipment, and room supplies in work area by monitoring levels, and restocking as required.
  • Assist with environmental monitoring, and pest control programs.
  • Maintain accurate work area documentation, and room logs, vivarium experimental rooms, and support areas, monitor room conditions including temperature, humidity, and lighting as required.
  • Assist in some rodent animal husbandry tasks as required, such as receive shipments of animals, receipt of food and bedding and other vivarium supplies, pack and dispose of vivarium waste, and euthanasia procedures as required.

Qualifications Include:

  • Good communication skills.
  • Ability to regularly lift up to 50 pounds and move heavy equipment in a safe manner.
  • Ability to stand, bend, reach, or crouch while working.
  • Availability to work on weekends and holidays as required to maintain compliance in animal care, providing oversight of animals 24/7.
  • High school diploma or GED preferred, computer skills a plus.

To apply for the position please send your resume to Rebecca Buonadies







 

Career Opportunities

  • PsychoGenics
  • 215 College Road, Paramus, NJ 07652
  • Tel: (914) 406-8000
  • Fax: (914) 406-8090