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| Psychosis |
| Schizophrenia is one of the most common psychiatric disorders and affects approximately 1% of the population. It is characterized by positive symptoms such as delusions and hallucinations, and negative symptoms such as incoherent speech, inattention, abnormal social behavior, lack of motivation and reduced sensorimotor function. The following tests have predictive and face validity for antipsychotic drugs. | |
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| Prepulse Inhibition of Startle |
| The acoustic startle reflex is a very basic response to strong exteroceptive stimuli. It is widely used to assess sensorimotor reactivity in animals and humans...more info |
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| Amphetamine Induced Hyperlocomotion |
| The test has predictive validity for some anti-psychotic drugs that normalize the hyperactivity and stereotypic behavior seen with amphetamine ...more info |
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| PCP Induced Hyperlocomotion |
| The test has predictive validity for some anti-psychotic drugs that normalize the hyperactivity and stereotypic behavior seen with PCP ...more info |
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| MK801 Induced Hyperlocomotion |
| The test has predictive validity for some anti-psychotic drugs that normalize the hyperactivity and stereotypic behavior seen with MK801 ...more info |
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| Apomorphine Induced Climbing |
| The test has predictive validity for anti-psychotic drugs that normalize the hyperactivity and stereotypic rearing and climbing behavior induced by Apomorphine ...more info |
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| DOI Induced Headshakes in mice and rats |
| This is used to evaluate potential antipsychotics and potential treatments for Tourette's syndrome ...more info |
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| Conditioned Avoidance Response |
| Conditioned avoidance Response (CAR), where an animal is trained to anticipate the occurrence of an aversive stimulus, is sensitive for the detection of both typical and atypical antipsychotic drugs |
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