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| Pain |
| Nocioception involves many neural systems in the brain and spinal cord (e.g. opiates, neuropeptide Y, serotonin, NMDA, GABA, etc.). Subtle changes in any of these systems (by pharmacological or genetic manipulation) may lead to changes in the sensitivity or threshold for stimuli. | |
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| Tail Flick |
| The tail flick test is a test for acute pain and measures the thermal response threshold. ...more info |
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| Hot Plate and Plantar Tests |
| The hot plate and plantar tests measure the thermal response threshold of the plantar region. ...more info |
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| Chemical-Induced Inflammatory Pain (Formalin, Carageenan) |
| These tests are useful in determining efficacy of steroidal and non-steroidal anti-inflammatory drugs and opiates. ...more info |
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| Writhing |
| This tests the ability of putative analgesic compounds to block a physiological response to a chemical irritant. ...more info |
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| Models of Neuropathic Pain (Bennett and Chung) |
| Two different neuropathic pain models, the sciatic nerve injury model (Bennett) and spinal nerve injury model (Chung), have been developed and successfully used to test therapeutic compounds. ...more info |
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| Randall-Selitto |
| This test measures mechanical hyperalgesia following inflammation caused by intraplantar injection of Complete Freund's Adjuvant (CFA). |
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