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Neuromorphology

Histology is used to characterize gross morphological changes such as lesions and neurodegeneration, or to measure structure volume and cell count. Immunohistochemistry can be used for neurochemical cell phenotyping, for the localization of neurons containing certain peptides, enzymes or receptors and for measurement of synaptic markers. Immunohistochemistry can also be used to measure neuronal activity. Using different antibodies, more than one protein can be visualized on a single section to provide information on co-expression and localization.

Neuronal death by apoptosis and necrosis, and cell proliferation in the adult mouse brain, can be measured by TUNEL staining, silver staining, and BrdU labeling, respectively.

PsychoGenics is able to offer the latest techniques in neuromorphology, including brain fixation, sectioning and staining together with sample digitalization and analysis, through our close relationship with NeuroScience Associates.