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| Drug Abuse Potential |
| The assessment of novel compounds for drug abuse potential provides critical information for the development of medications with maximized therapeutic benefit and minimized risk for abuse. These tests assess the abuse potential of novel compounds that exhibit specific effects (such as psychostimulant, depressant or hallucinogenic effects) on the central nervous system. The following tests are offered to assess the putative abuse liability of psychoactive drugs. | |
| Locomotor Sensitization |
| Repeated intermittent administration of psychostimulants in rodents causes an increase in locomotor activity that is higher in magnitude to that induced by a single injection. This phenomenon is known as locomotor sensitization...more info |
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| Intravenous Self-Administration |
| Rats are trained to self-administer a drug of abuse by lever pressing in an operant box. If a novel compound can substitute for the drug of abuse this indicates potential drug abuse liability ...more info |
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| Drug Discrimination |
| Rats are trained to discriminate between a drug of abuse (e.g., cocaine) and vehicle in a two- lever operant design ...more info |
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