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| Depression & Sexual Function |
| Depression is the most prevalent psychiatric disorder characterized by a state of sadness, despair, discouragement, and hopelessness. Other symptoms may include apathy, withdrawal from social contact, an inability to experience pleasure, changes in appetite and sleep patterns, low energy levels, difficulty concentrating, and thoughts of suicide. Key aspects of these disease states can be recapitulated in rodents in the following tests. | |
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| Differential Reinforcement of Low Rate of Responding(DRL) |
| This is an operant test used to measure motor impulsivity involving behavioral suppression and withholding of a response for a period or time...more info |
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| Forced Swim in Mice and Rats |
| Rats or mice in the forced swim test become immobile and cease trying to escape, reflecting a depressive-like state that is readily influenced by a wide variety of antidepressants ...more info |
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| Tail Suspension |
| This test is thought to reflect a depressive-like state and can be reduced by a large variety of clinically active antidepressants ...more info |
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| Olfactory Bulbectomy in Rats |
| Removal of the olfactory bulb in rats is associated with behavioral abnormalities including hyperactivity. Chronic administration of antidepressants reduces the olfactory bulbectomy-induced hyperactivity in rats ...more info |
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| Sexual Behavior in Male Rats |
| Drugs can be tested to determine their effects (beneficial or detrimental) on the latency and frequency of sexual behaviors ...more info |
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| Novelty Suppressed Feeding |
| This test measures the latency of an animal to approach and eat a familiar food in an aversive environment and is sensitive to chronic antidepressant treatment ...more info |
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