Microdialysis – Skin Microdialysis
Measurement of the levels of neurochemicals such as histamine in the skin can provide insight into the stimulus for an inflammatory response and the mechanism of action of anti-inflammatory treatments.
Top - Administration of the skin irritant ovalbumin at time = 0 produced a rapid and robust increase in the extracellular level of histamine in guinea pig skin. Bottom - Topical application of 1% capsaicin (horizontal bar) to the abdominal skin of anesthetized rats produced a marked increase in PGE2 levels but almost no effect on histamine levels.
Topical application of 1% capsaicin (horizontal bar) to the abdominal skin of anesthetized rats produced a marked increase in PGE2 levels but almost no effect on histamine levels.
