Radial Arm Maze is a spatial navigation task that can be used to tax working memory processes in rodents using the animal's natural tendency to explore novel locations. The procedure assesses the animals' ability to distinguish a novel stimulus, in this case a novel arm on the radial arm maze from a familiar stimulus following a single presentation. Over time animals make fewer and fewer errors. Recognition of the novel stimulus results in an appetitive food reward. The Maze yields different measures of working and spatial memory.

The number of errors is defined as entries into an arm which has already been visited and from which the food reward has already been collected.

The PDE4 inhibitor Rolipram and the H3 antagonist GSK are able to reverse scopolamine-induced deficits in Radial Arm Maze as measured by Number of Errors.

Entries to repeat is defined as the number of entries into non-visited arms before the first error occurs (i.e., the first repeat visit).

The H3 antagonist GSK reversed scopolamine-induced deficits in RAM when assessed by the Entries to Repeat.