Schizophrenia & Mania – PCP-induced Deficits in Social Interaction (negative symptoms)
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Social isolation is part of the negative symptoms associated with schizophrenia. To date, atypical, but not typical, antipsychotics have been shown to be partially effective in treating the negative symptoms in schizophrenic patients. In rodents, chronic administration of PCP causes deficits in social interaction which can be reversed by treatment with clozapine. This assay can be used to screen the efficacy of novel antipsychotics to treat social isolation and withdrawal.
Acute administration of atypical (clozapine, 2.5 mg/kg; i.p.) but not typical (haloperidol) antipsychotics reverses phencyclidine-induced disruption of social interaction in Sprague Dawley rats.
Anti-manic compounds in PPI 8
Panels A and B show the effects of acute administration of amphetamine in groups of rats exposed to MAM or vehicle in utero. Acute administration of amphetamine (1 mg/kg) elicited hyperactivity in both saline- and MAM-exposed rats, compared to acute administration of vehicle (*p<0.001). However, the locomotor-activating effects of amphetamine were significantly greater in MAM- versus saline-exposed subjects (#p<0.05).
