Model for NASH and Cancer
- STAM™ is a model for non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), created by the combination of chemical and dietary interventions in C57BL/6 mice.
- STAM™ mice can be used as a model for metabolic disorders, inflammatory and fibrotic diseases, and cancer.
- 100% of STAM™ mice develop HCC by 20 weeks.
Pathological process of STAM™ mice.
Macroscopic and histological features of STAM™ mice.
The mice develop steatosis at 6 weeks, steatohepatitis at 8 weeks, chronic fibrosis at 12 weeks and HCC at 20 weeks of age.
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