Mouse Models of Huntington’s Disease

Comprehensive phenotyping and preclinical testing platform for efficacy and toxicity.

Huntington’s Disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor disturbance, cognitive decline and psychiatric symptoms. It is caused by an unstable expansion of CAG repeats in the huntingtin gene. Together with the CHDI Foundation, PsychoGenics has worked on HD for over 8 years.

• We have extensively phenotyped multiple transgenic (R6/2, YAC128 and BAC HD) and knock-in (Q111, Q140 and Q175) mouse models of HD.
• We offer a comprehensive in vivo and in vitro battery of preclinical tests to evaluate the effects of new chemical entities, biologics or genes.
• Tests offered include a detailed behavioral assessment of motor, general health, cognitive and psychiatric endpoints using standard assays and proprietary automated testing technology.
• We also offer complementary in vitro endpoints including sample collection (CSF, brain, plasma), molecular and cell biology, electrophysiology and neurochemistry.
• PsychoGenics has unparalleled experience, having screened over 100 compounds in mouse models of Huntington’s Disease.

Learn more about our models of HD: