Selected Publication with PGI Scientists as Authors

Liu, F., M. Day, et al. (2008). "Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory." Nat Neurosci 11(3): 334-43.
Navarra, R., T. A. Comery, et al. (2008). "The 5-HT(2C) receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test." Behav Brain Res 188(2): 412-5.
Navarra, R., R. Graf, et al. (2008). "Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test." Prog Neuropsychopharmacol Biol Psychiatry 32(1): 34-41.
Hirst, W. D., T. H. Andree, et al. (2008). "Correlating Efficacy in Rodent Cognition Models with In Vivo 5-HT1A Receptor Occupancy by a Novel Antagonist, WAY-101405." J Pharmacol Exp Ther.
Feuerstein, G. Z., M. M. Zaleska, et al. (2008). "Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke." J Cereb Blood Flow Metab 28(1): 217-9.
Day, M., J. B. Pan, et al. (2007). "Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test." Biochem Pharmacol 73(8): 1123-34.
Day, M. and R. F. Langston (2006). "Post-training N-methyl-D-aspartate receptor blockade offers protection from retrograde interference but does not affect consolidation of weak or strong memory traces in the water maze." Neuroscience 137(1): 19-28.
Day, M. and M. Good (2005). "Ovariectomy-induced disruption of long-term synaptic depression in the hippocampal CA1 region in vivo is attenuated with chronic estrogen replacement." Neurobiol Learn Mem 83(1): 13-21.
Day, M., A. Sung, et al. (2005). Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning." Behav Brain Res 164(1): 128-31.
Day, M., R. Langston, et al. (2003). "Glutamate-receptor-mediated encoding and retrieval of paired associate learning." Nature 424(6945): 205-9.
Day, M. and R. G. Morris (2001). "Memory consolidation and NMDA receptors: discrepancy between genetic and pharmacological approaches." Science 293(5531): 755.
Morris, R. G., E. I. Moser, et al. (2003). "Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory." Philos Trans R Soc Lond B Biol Sci 358(1432): 773-86. 25.
Morris, R. G. M., and Day, M (2004) Place and flavors: one-trial paired associate learning as a model of episodic-like memory in the rat" In Cognition and Emotion: T. Ono, G. Matsumoto, R.R. Llinas, A. Berthoz, R. Norgren, H. Nishijo, R Tamura. Elsevier Press, Amsterdam, 2003. Volume 1250, October 2003, Pages 183-198
Good, M., Day, M.,et al (1999) Cyclical changes in endogenous levels of estrogen modulate the induction of LTD and LTP in the hippocampal CA1 region. European Journal of Neuroscience, Vol 11. pp 4476 – 4480.
Day, M., Wan, H et al Cognitive Endpoints in Attention, Impulsivity and Episodic Memory as Disease Biomarkers: Optimizing the Congruency of Preclinical Models to the Clinic. Current Opinions in Investigational Drugs.
Wan, H., Day, M et al Biomarkers for Alzheimer’s Disease: Translational Medicine Approaches in Development of Disease Modifying Therapeutics. American Drug Discovery.
Day M, Rutkowski JL, Feuerstein GZ. Translational medicine-A paradigm shift in modern drug discovery and development: the role of biomarkers. In: Guzman CA, Feuerstein G, eds. Pharmaceutical Biotechnology. Austin: Landes Bioscience.
Li, A., Baum, MJ, et al Building a scientific framework for studying hormonal effects on behaviour and on the development of sexually dimoprphic nervous system. International Journal of Neurotxicity
Hughes, Z, Dwyer, J et al WAY-200070 a Selective Agonist of ERB as a Potential Novel Anxiolitic/Antidepressant Agent. Neuropharmacology
Two mouse models with predictive validity for treatment of bipolar disorders: Amphetamine / Chlordiazepoxide – Induced Hyperactivity and Prepulse Inhibition of Acoustic Startle. Click here for the Society for Neuroscience 2005 poster.
January edition of "Nature" cites works performed by PsychoGenics-- Click here for abstract.
Consortium undertakes collaborative initiative to screen FDA-approved compounds for treatment of ALS in mice
April 16, 2003. A pilot study has been launched to test three FDA-approved compounds for their effect in treating ALS to help determine whether clinical trials are warranted. The two-phase study is a collaboration of The ALS Association (ALSA), The Robert Packard Center for ALS Research at Johns Hopkins and Project A.L.S. Read More.