Motor Function – Rotarod
Motor coordination and exercise capacity are assessed by rotarod test. Fatigue as a result of treatment can be also assessed in this assay. Tests are performed on separate days, with multiple trials per day. Mice are placed on the rotarod and the speed is gradually and uniformly increased over a maximum period of time. The time that each mouse remains on the rotating rod before falling is recorded. The assay is commonly used in transgenic models phenotyping as shown in the examples below.
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Pretreament of rats with haloperidol, but not olanzapine, significantly decreased amphetamine-induced hyperlocomotor activity.
