Motor Function – Open Field
The open field test (OF) is used to assess locomotor activity in mice and rats, and can also be used to measure fatigue. This high-throughput test is recommended as an initial screening for evaluation of a novel phenotype or investigational compound. Each testing enclosure is configured to divide the open field area into a center and periphery zone that also allows basic assessment of anxiety associated with placement into novel environment. Animals that have higher anxiety (or lower levels of activity) tend to stay in the corners of the OF enclosures. Animals that have high levels of activity and low levels of anxiety tend to spend more time in the center of the open field.
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Pretreament of rats with haloperidol, but not olanzapine, significantly decreased amphetamine-induced hyperlocomotor activity.
