Models of Neuropathic Pain (Bennett and Chung)
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      Neuropathic pain is a prevalent human chronic pain disorder affecting 1.6% of the population. It is caused by damage to peripheral somatosensory nerves resulting in chronic pain in response to otherwise innocuous stimuli. This condition is extremely difficult to manage because of the lack of effect of standard analgesics. Two different neuropathic pain models, the sciatic nerve injury model (Bennett) and spinal nerve ligation model (Chung), have been developed and successfully used to test therapeutic compounds.

      Neuropathic Pain: Sciatic Nerve Ligation (Bennet)
      AB
      Pretreatment with gabapentin (A) or carbamazepine (B) increases the latency to lift the paw from a cold plate in sciatic-nerve ligated rats.
      Neuropathic Pain: Spinal Nerve Ligation (Chung)
      AB
      Pretreatment with morphine (A) or tramadol (B) decreases mechanical hyperalgesia in spinal-nerve ligated rats.