Microdialysis and biosensor techniques allow scientists to monitor the release, uptake and metabolism of neurotransmitters and other bioactive molecules implicated in intracellular signaling within the extracellular space of brain and other tissues in awake, freely moving animals. The method can be used in naïve and genetically modified animals, combined with certain behaviors, blood and CSF sampling. PsychoGenics acquired analytical equipment and experienced scientists from Lundbeck Research USA to provide a broad suite of microdialysis and analytical services that complement PsychoGenics’ in vivo testing capabilities.

Local release/overflow of the following neurotransmitters can be monitored:

  • Acetylcholine
  • Dopamine
  • Gamma-amino butyric acid (GABA)
  • Histamine
  • Norepinephrine
  • Serotonin (5-HT)
  • Glutamate
  • Glycine

Additional neuroactive molecules can be monitored:

  • Choline
  • Adenosine, cAMP and cGMP
  • Glucose / lactate / pyruvate
  • Kynurenine pathway metabolites (3-HK, KYN, KYNA, 3-HAA, QUIN, AA, TRP, NAD)
  • Interleukins (IL-1β, IL-6)
  • Tumor necrosis Factor (TNFα)
  • Interleukin-1 receptor antagonist (IL-1RA)
  • Large peptides (α-sinuclein)

The following administration routes are available:

  • Systemically (i.m., i.p., s.c., i.v.)
  • Locally (i.e. perfused via the microdialysis probe, also referred to as “reverse” or “retrodialysis”)
  • Centrally (i.c.v.)
  • Several routes combined

Click on any of the tests for a complete description.

  • PsychoGenics
  • 765 Old Saw Mill River Road, Tarrytown, NY 10591
  • tel: (914) 406-8019
  • fax: (914) 593-0645