Microdialysis
Microdialysis and biosensor techniques allow scientists to monitor the release, uptake and metabolism of neurotransmitters and other bioactive molecules implicated in intracellular signaling within the extracellular space of brain and other tissues in awake, freely moving animals. PsychoGenics established an alliance with Dr. Jan Kehr at Pronexus Analytical in 2010 to provide a broad suite of microdialysis and analytical services that complement PsychoGenics’ in vivo testing capabilities.
Microdialysis can be used to monitor many bioactive molecules including:
- Dopamine, serotonin, norepinephrine and their metabolites
- Histamine, acetylcholine, choline
- Glutamate, aspartate, glycine, GABA
- Physiological amino acids – primary and secondary
- NO biomarkers - nitrite/nitrate, arginine/citrulline/ornithine
- Kynurenic acid, quinolinic acid
- Adenosine, melatonin
- cAMP, cGMP, free fatty acids
- Glucose, lactate, pyruvate, urea
- Reactive oxygen species
- Neuropeptides, protein fragments
- Cytokines, interleukins
- Hormones, trophic factors, growth factors
Click on any test for a complete description.
- Monitoring Neurotransmitters in Awake Rats or Mice
- Simultaneous Microdialysis and Behavioral Monitoring
- Pharmacokinetic/Pharmacodynamic Determinations
- Skin Microdialysis
- Muscle Microdialysis
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