Neurogenesis – In Vivo Neurogenesis – Cell proliferation
Progenitor cell proliferation is the first step in the process of neurogenesis and several antidepressants have been shown to increase cell proliferation in the hippocampus. The GC/MS-based method has been validated by assessing the effects of neurogenic antidepressant drugs of different classes on hippocampal progenitor cell proliferation
Mice were treated for 3 weeks with the SSRI fluoxetine, the tricyclic imipramine, or the SNRI, venlafaxine and compared to one week treatment with the α2-adrenergic/5-HT2/3 antagonist mirtazapine. 2H2O was administered in the drinking water to label proliferating cells. Progenitor cells were isolated by Percoll gradient fractionation and labeling of DNA was measured by GC/MS. * indicates p < .05, n = 8.
Pretreament of rats with haloperidol, but not olanzapine, significantly decreased amphetamine-induced hyperlocomotor activity.
