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| Fear Potentiated Startle (FPS) in Rats |
| Services - Anxiety - Fear Potentiated Startle (FPS) in Rats | |
An auditory startle response can be augmented by presenting the startle-eliciting noise with a stimulus that has previously been paired with an electric shock. The augmented startle response is called the fear-potentiated startle (FPS) and is considered a measure of fear. Clinically effective anxiolytics including benzodiazepines decrease or block the FPS. | |
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| Anxiolytic compounds such as chlordiazepoxide (CDP) or alprazolam significantly and dose-dependently decrease FPS. |
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