Schizophrenia & Mania – DOI-Induced Headshakes
Click here to view other Psychiatric disorders models
In rodents, administration of the serotonin 5-HT2A/2C receptor agonist hallucinogenic drug DOI induces head shakes and “wet dog” shakes. Atypical antipsychotics (e.g., clozapine, olanzapine, and risperidone) and typical antipsychotics such as haloperidol have been shown to inhibit DOI-induced headshakes in rodents. This model can be used to screen novel antipsychotic compounds.
Pretreatment of Sprague Dawley rats with the 5-HT2A/C receptor antagonist ketanserin, the typical antipsychotic haloperidol, and the atypical antipsychotics clozapine and olanzapine, significantly decrease the number of headshakes induced by DOI (10 mg/kg) over a period of 10 minutes.
Anti-manic compounds in PPI 8
As noted above, pre-pulse inhibition is enhanced by the administration of antipsychotic medications such as clozapine or haloperidol. Similarly, administration of valproate, lithium or lamotrigine enhances PPI in mice. Therefore, PPI provides a preclinical screen for potential therapeutic compounds for the treatment of bipolar disorder.
