Spontaneous Alternation
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                                                                      Mice have an innate tendency to explore their environment. Successful exploration depends on the ability to avoid places recently visited, where food may have been depleted or absent. Spontaneous Alternation or "Y-maze" is an ethologically based test that does not involve reward delivery. Mice with compromised "working memory" functions cannot hold information regarding places just visited in their working memory and therefore show decreased spontaneous alternation.

                                                                      APP/PS1 mice (approx 3 months of age) are seen to be significantly more hyperactive compared to their Wild Type littermates, as determined by the total number of arm entries (A), but have spatial memory deficits as is evident from fewer correct alternations (B).