PCP/Amphetamine/MK801 Induced Hyperlocomotion
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                                                                                  In humans, acute administration of PCP causes schizophrenia-like symptoms. This is manifested in rodents as an increase in locomotor activity. This test is used with the open field activity chambers and measures locomotion, rearing, and stereotypic activity under amphetamine/PCP/MK801 induced conditions. The test has predictive validity for some anti-psychotic drugs that normalize the hyperactivity and stereotypic behavior seen with amphetamine and PCP.

                                                                                  PCP, administered at 30 minutes, increases locomotor activity of C57 mice.
                                                                                  AB

                                                                                  Atypical antipsychotic, Olanzepine, attenuates PCP-induced activity as seen as a function of distance travelled over time (A) and total distance travelled (B).

                                                                                  Atypical antipsychotic Clozapine also attenuates PCP-induced activity.
                                                                                  Typical antipsychotics, such as non-sedative doses of haloperidol have no effect on PCP-induced activity.
                                                                                  AB
                                                                                  Atypical antipsychotics (Clozapine) have no effect on amphetamine-induced activity in mice, whereas typical antipsychotics (Haloperidol) attenuate amphetamine induced activity as can be seen from distance travelled over time (A) and total distance travelled (B).
                                                                                  Pretreament of rats with haloperidol but not olanzapine, significantly decreases ampehtamine-induced locomotor activity.
                                                                                  AB

                                                                                  Acute administration of the NMDA receptor antagonist MK-801 causes hyperactivity in rodents. Antispsychotic agents, such as clozapine, attenuate MK-801-induced hyperactivity as seen as a function of distance travelled over time (A) and total distance travelled (B).